Sh2d1b1 Gene Summary [Mouse]
Enables phosphotyrosine residue binding activity. Involved in leukocyte activation involved in immune response and positive regulation of natural killer cell mediated immunity. Acts upstream of or within several processes, including natural killer cell inhibitory signaling pathway; regulation of natural killer cell mediated cytotoxicity; and regulation of peptidyl-tyrosine phosphorylation. Orthologous to human SH2D1B (SH2 domain containing 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh2d1b1 |
| Official Name | SH2 domain containing 1B1 [Source:MGI Symbol;Acc:MGI:1349420] |
| Ensembl ID | ENSMUSG00000102418 |
| Bio databases IDs | |
| Aliases | SH2 domain containing 1B1 |
| Synonyms | EAT-2, EAT-2A, LOC100910879, RGD1563935, Sh2d1b, SH2 domain containing 1B, SH2 domain containing 1B1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh2d1b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown