Chd5 Gene Summary [Mouse]
Enables histone H3K27me3 reader activity; histone binding activity; and histone deacetylase binding activity. Involved in several processes, including cerebral cortex neuron differentiation; positive regulation of signal transduction by p53 class mediator; and sperm DNA condensation. Located in heterochromatin and nucleus. Part of NuRD complex. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human CHD5 (chromodomain helicase DNA binding protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chd5 |
| Official Name | chromodomain helicase DNA binding protein 5 [Source:MGI Symbol;Acc:MGI:3036258] |
| Ensembl ID | ENSMUSG00000005045 |
| Bio databases IDs | |
| Aliases | chromodomain helicase DNA binding protein 5 |
| Synonyms | 4930532L22RIK, AW060752, B230399N07, B230399N07Rik, chromodomain helicase DNA binding protein 5, LOC686986, PMNDS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- histone binding
- PHD zinc finger
- transcription regulator
- protein binding activity, bridging
- SNF2-related domain
- helicase superfamily c-terminal domain
- CHD subfamily II, SANT-like domain
- histone deacetylase binding
- chromatin binding
- enzyme
- protein binding
- CHDNT (NUC034) domain
- Helicase conserved C-terminal domain
- CHD subfamily II, DUF1087
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- PHD finger superfamily
- Class II histone deacetylase complex subunits 2 and 3
- DEAD-like helicases superfamily
- Chromo (CHRromatin organization MOdifier) domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- CHDCT2 (NUC038) domain
Pathways
Biological processes and signaling networks where the Chd5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- organismal death
- Crohn disease
- metastasis
- advanced cancer
- tumorigenesis
- Parenti-Mignot neurodevelopmental syndrome
- Alzheimer disease
- neurodevelopmental disorder
- Parkinson disease
role in cell
- migration
- expression in
- proliferation
- growth
- differentiation
- abnormal morphology
- number
- invasion
- invasion by
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chd5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of cell proliferation
- sperm chromatin condensation
- regulation of transcription from RNA polymerase II promoter
- cerebral cortex neuron differentiation
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- nuclear speck
- membrane
- NuRD complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- histone binding
- metal ion binding
- helicase activity
- chromatin binding