Plcl1 Gene Summary [Mouse]
Predicted to enable GABA receptor binding activity and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within gamma-aminobutyric acid signaling pathway and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Is expressed in nervous system and vibrissa. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plcl1 |
| Official Name | phospholipase C-like 1 [Source:MGI Symbol;Acc:MGI:3036262] |
| Ensembl ID | ENSMUSG00000038349 |
| Bio databases IDs | |
| Aliases | phospholipase C-like 1 |
| Synonyms | C230017K02, C230017K02Rik, LOC84587, phospholipase C-like 1, phospholipase C like 1 (inactive), PLCE, PLC-L, PLDL1, PPP1R127, PRIP, PRIP-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-specific phospholipase C, Y domain
- enzyme
- Cdc25 domain
- phospholipase C
- receptor binding
- Pleckstrin homology-like domain
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- Protein kinase C conserved region 2 (CalB)
- Pleckstrin homology domain
- C2 domain
Pathways
Biological processes and signaling networks where the Plcl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Leptin Signaling in Obesity
- Melatonin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- systemic lupus erythematosus
- rheumatoid arthritis
- major depression
- obesity
- asthma
- diabetes mellitus
- renal cell carcinoma
- insulin resistance
role in cell
- phosphorylation in
- expression in
- apoptosis
- number
- quantity
- differentiation
- migration
- invasion by
- exocytosis by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plcl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- regulation of synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- phospholipase C activity