Fhit Gene Summary [Mouse]
This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | Fhit |
| Official Name | fragile histidine triad gene [Source:MGI Symbol;Acc:MGI:1277947] |
| Ensembl ID | ENSMUSG00000060579 |
| Bio databases IDs | |
| Aliases | fragile histidine triad gene |
| Synonyms | AP3Aase, Fra14A2, FRA3B, fragile histidine triad diadenosine triphosphatase, fragile histidine triad gene, LOC102552150 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fhit often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- adenylylsulfatase
- linear amide carbon-nitrogen bond hydrolase
- nickel ion binding
- adenylylsulfate-ammonia adenylyltransferase
- Bis(5'-adenosyl)-triphosphatase
- enzyme
- protein binding
- identical protein binding
- phosphorylation site
- HIT_like
Pathways
Biological processes and signaling networks where the Fhit gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- colon carcinoma
- colorectal cancer
- dementia
- schizophrenia
- neoplasia
- organismal death
- prostate cancer
- epithelial cancer
- major depression
role in cell
- cell death
- apoptosis
- cell viability
- expression in
- formation
- activation in
- proliferation
- migration
- survival
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fhit gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- purine nucleotide metabolic process
- signal transduction by p53 class mediator resulting in induction of apoptosis
- diadenosine triphosphate catabolic process
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- fibrillar center
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- adenylylsulfate-ammonia adenylyltransferase activity
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- adenosine 5'-monophosphoramidase activity
- bis(5'-adenosyl)-triphosphatase activity
- adenylylsulfatase activity