Prg4 Gene Summary [Mouse]
Predicted to enable polysaccharide binding activity and scavenger receptor activity. Acts upstream of or within hematopoietic stem cell proliferation; negative regulation of interleukin-6 production; and regulation of cell population proliferation. Located in extracellular space. Is expressed in brain; larynx; musculoskeletal system; and spinal component of peripheral nervous system. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prg4 |
| Official Name | proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) [Source:MGI Symbol;Acc:MGI:1891344] |
| Ensembl ID | ENSMUSG00000006014 |
| Bio databases IDs | |
| Aliases | proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) |
| Synonyms | C77892, CACP, DOL54, HAPO, JCAP, LUBRICIN, MSF, PROTEOGLYCAN 4, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein), SZP, Tpr |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- Family of unknown function (DUF5585)
- Cornifin (SPRR) family
- HX
- TonB polyproline region
- Somatomedin B domain
Pathways
Biological processes and signaling networks where the Prg4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- osteoarthritis
- hepatocellular carcinoma
- liver cancer
- Jacobs syndrome
- lung adenocarcinoma
- lung adenocarcinoma formation
- hereditary disorder
- camptodactyly
- flu
regulates
role in cell
- differentiation
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- interchromatin granule cluster fractions
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prg4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- scavenger receptor activity
- extracellular matrix structural constituent conferring compression resistance
- polysaccharide binding