Gcat Gene Summary [Mouse]
Predicted to enable glycine C-acetyltransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-threonine catabolic process to glycine and biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human GCAT (glycine C-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gcat |
| Official Name | glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) [Source:MGI Symbol;Acc:MGI:1349389] |
| Ensembl ID | ENSMUSG00000006378 |
| Bio databases IDs | |
| Aliases | glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) |
| Synonyms | AKB Ligase, glycine C-acetyltransferase, glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase), KBL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gcat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aminotransferase class-V
- 8-amino-7-oxononanoate synthase
- 5-aminolevulinic acid synthase
- glycine C-acetyltransferase
- AAT_I
- enzyme
- Aminotransferase class I and II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- epithelial cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- kidney carcinoma
- renal cancer
- osteoarthritis
- hearing loss
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial inner membrane
- nucleoplasm
- nuclear speckles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gcat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular amino acid metabolic process
- biosynthetic process
- threonine catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- glycine C-acetyltransferase activity