Tnfsf14 Gene Summary [Mouse]
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokine activity; and identical protein binding activity. Acts upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Used to study IgA glomerulonephritis. Orthologous to human TNFSF14 (TNF superfamily member 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf14 |
| Official Name | tumor necrosis factor (ligand) superfamily, member 14 [Source:MGI Symbol;Acc:MGI:1355317] |
| Ensembl ID | ENSMUSG00000005824 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor (ligand) superfamily, member 14 |
| Synonyms | CD258, HVEM-L, LIGHT, LTg, Ly113, TNF superfamily member 14, TNLG1D, tumor necrosis factor (ligand) superfamily, member 14, tumour necrosis factor (ligand) superfamily, member 14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfsf14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TNF homology domain
- cytoplasmic domain
- TNF
- caspase inhibitor activity
- transmembrane domain
- protein binding
- receptor binding
- cytokine
- identical protein binding
Pathways
Biological processes and signaling networks where the Tnfsf14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypertension
- splenomegaly
- pulmonary fibrosis
- multiple sclerosis
- hepatitis
- lymphadenopathy
- experimental autoimmune encephalomyelitis
- diabetic nephropathy
- systemic lupus erythematosus
role in cell
- phosphorylation in
- expression in
- activation in
- apoptosis
- proliferation
- production in
- growth
- cell death
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell borders
- intracellular space
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfsf14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to mechanical stimulus
- immune response
- T cell chemotaxis
- T cell costimulation
- signal transduction
- apoptotic process
- T cell proliferation
- positive regulation of T cell chemotaxis
- T cell activation
- positive regulation of myoblast differentiation
- T cell homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- receptor binding