Nek3 Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in several processes, including neuron projection morphogenesis; protein phosphorylation; and regulation of tubulin deacetylation. Predicted to be located in axon and cytoplasm. Is expressed in several structures, including brain; genitourinary system; intestine; and spleen. Orthologous to human NEK3 (NIMA related kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nek3 |
| Official Name | NIMA (never in mitosis gene a)-related expressed kinase 3 [Source:MGI Symbol;Acc:MGI:1344371] |
| Ensembl ID | ENSMUSG00000031478 |
| Bio databases IDs | |
| Aliases | NIMA (never in mitosis gene a)-related expressed kinase 3 |
| Synonyms | HSPK36, NIMA (never in mitosis gene a)-related expressed kinase 3, NIMA-related kinase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nek3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Kinase-like
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal adenocarcinoma
- esophageal carcinoma formation
- Waldenström macroglobulinemia
role in cell
- survival
- migration
- number
- morphogenesis
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nek3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- neuron projection morphogenesis
- regulation of tubulin deacetylation
- establishment of cell polarity
- protein phosphorylation
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity