Ptprb Gene Summary [Mouse]
Predicted to enable cadherin binding activity. Involved in angiogenesis and peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Predicted to be located in membrane. Predicted to be part of receptor complex. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and umbilical artery. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ptprb |
| Official Name | protein tyrosine phosphatase, receptor type, B [Source:MGI Symbol;Acc:MGI:97809] |
| Ensembl ID | ENSMUSG00000020154 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, B |
| Synonyms | 3230402H02Rik, C130094E24, HPTPB, HPTP-BETA, HPTP-β, LOC100504392, LOC102546841, LOC688895, protein tyrosine phosphatase receptor type B, protein tyrosine phosphatase, receptor type, B, PTPB, Ptprbl1, Ptpz, PTP-β, Rptpb, R-PTP-BETA, R-PTP-β, VE-PTP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein-tyrosine-phoshatase
- catalytic domain
- carbonic anhydrase domain
- Protein tyrosine phosphatase, catalytic domain
- beta-trefoil_Ricin_MRC-like
- Fibronectin type 3 domain
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- TM proximal of protein tyrosine phosphatase, receptor type J
- Protein-tyrosine phosphatase
- FNIII-like repeat
- cytoplasmic domain
- transmembrane receptor protein tyrosine phosphatase
- FN3
- spacer domain
- transmembrane domain
- intracellular domain
- cadherin binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ptprb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glomerulosclerosis
- retinal neovascularization
- diabetes mellitus
- interstitial fibrosis
- papillary thyroid carcinoma
- papillary thyroid cancer
role in cell
- expression in
- migration
- activation in
- adhesion
- permeability
- phosphorylation in
- differentiation
- accumulation
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- tertiary granule membrane
- specific granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- protein dephosphorylation
- dephosphorylation
- phosphate-containing compound metabolic process
- glial cell migration
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- transmembrane receptor protein tyrosine phosphatase activity