Rnf168 Gene Summary [Mouse]
Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; histone H2AK15 ubiquitin ligase activity; and ubiquitin binding activity. Involved in isotype switching. Acts upstream of or within cellular response to UV and regulation of protein localization. Part of DNA repair complex. Is expressed in central nervous system and genitourinary system. Used to study RIDDLE syndrome. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rnf168 |
| Official Name | ring finger protein 168 [Source:MGI Symbol;Acc:MGI:1917488] |
| Ensembl ID | ENSMUSG00000014074 |
| Bio databases IDs | |
| Aliases | ring finger protein 168 |
| Synonyms | 3110001H15Rik, FLJ35794, hRNF168, LOC684436, RIDL, ring finger protein 168 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf168 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- UDM1_RNF168_RNF169-like
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- chromatin binding
- ubiquitin binding
- enzyme
- Ring finger domain
- protein binding
- binding protein
- RING-type zinc-finger
- MIU2_RNF168-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Rnf168 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- RIDDLE syndrome
role in cell
- damage in
- production in
- formation
- formation in
- interaction in
- bleomycin sensitivity
- focus formation
- non-homologous end joining
- recruitment in
- homologous recombination repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf168 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- negative regulation of transcription elongation from RNA polymerase II promoter
- protein K63-linked ubiquitination
- response to DNA damage stimulus
- double-strand break repair via nonhomologous end joining
- regulation of gene expression, epigenetic
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
- response to ionizing radiation
- isotype switching
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- ubiquitin ligase complex
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin binding
- histone binding
- metal ion binding
- K63-linked polyubiquitin binding
- nucleosome binding
- chromatin binding