RNF168
RNF168 Gene Summary
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | RNF168 |
| Official Name | ring finger protein 168 [Source:HGNC Symbol;Acc:HGNC:26661] |
| Ensembl ID | ENSG00000163961 |
| Bio databases IDs | |
| Aliases | ring finger protein 168 |
| Synonyms | 3110001H15Rik,FLJ35794,hRNF168,LOC684436,RIDL,ring finger protein 168 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- UDM1_RNF168_RNF169-like
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- chromatin binding
- ubiquitin binding
- enzyme
- Ring finger domain
- protein binding
- binding protein
- RING-type zinc-finger
- MIU2_RNF168-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the RNF168 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- UBC
- KDM1A
- ZRANB1
- USP14
- STAT1
- TP53BP1
- PALB2
- BCL10
- DBN1
- UBE2N
disease
- RIDDLE syndrome
regulated by
- sirolimus
- HTT
- SENP1
- RPS6KB1
- NSC 686288
- RPS6KB2
- camptothecin
- RPTOR
- PIAS4
- ZEB1
regulates
- BLM
- histone H3
- FANCA
- TP53BP1
- BARD1
- COL7A1
- H2AX
- FANCD2
role in cell
- damage in
- production in
- formation
- formation in
- interaction in
- bleomycin sensitivity
- focus formation
- non-homologous end joining
- recruitment in
- homologous recombination repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RNF168 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- negative regulation of transcription elongation from RNA polymerase II promoter
- protein K63-linked ubiquitination
- response to DNA damage stimulus
- double-strand break repair via nonhomologous end joining
- regulation of gene expression, epigenetic
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
- response to ionizing radiation
- isotype switching
- double-strand break repair
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- ubiquitin ligase complex
- cytosol
- macromolecular complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin binding
- histone binding
- metal ion binding
- K63-linked polyubiquitin binding
- nucleosome binding
- chromatin binding