Bcl10 Gene Summary [Mouse]
Enables CARD domain binding activity; identical protein binding activity; and signaling adaptor activity. Involved in several processes, including antifungal innate immune response; non-canonical NF-kappaB signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; lymphocyte apoptotic process; and regulation of signal transduction. Located in cytosol; immunological synapse; and membrane raft. Part of CBM complex and polkadots. Is active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and vibrissa follicle. Human ortholog(s) of this gene implicated in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Bcl10 |
| Official Name | B cell leukemia/lymphoma 10 [Source:MGI Symbol;Acc:MGI:1337994] |
| Ensembl ID | ENSMUSG00000028191 |
| Bio databases IDs | |
| Aliases | B cell leukemia/lymphoma 10 |
| Synonyms | B CELL CLL/LYMPHOMA 10, B cell leukaemia/lymphoma 10, B cell leukemia/lymphoma 10, BCL10 immune signaling adaptor, BCL10, immune signaling adaptor, C81403, CARMEN, c-E10, CIPER, CLAP, IMD37, ME10, MGCT, MMS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- ubiquitin protein ligase binding
- transcription regulator
- transcription co-activator
- protein kinase binding
- protease binding
- oligomerization domain
- NF-kappaB binding
- protein binding activity, bridging
- transcription factor binding
- caspase activator
- protein binding
- identical protein binding
- Caspase recruitment domain
- binding protein
- homodimerization domain
- protein homodimerization
- serine threonine rich domain
- kinase activator
- Death Domain Superfamily of protein-protein interaction domains
- protein heterodimerization
- MALT1-binding domain
Pathways
Biological processes and signaling networks where the Bcl10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- epithelial cancer
- epithelial neoplasia
- cancer
- systemic lupus erythematosus
- Sézary syndrome
- glioma
- glioma formation
- gastric cancer
- colorectal cancer
role in cell
- proliferation
- phosphorylation in
- apoptosis
- survival
- quantity
- expression in
- activation in
- growth
- number
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- perinuclear region
- Nucleus
- lysosome
- immunological synapses
- cytosol
- nucleoplasm
- cytoplasmic microtubule
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of T cell activation
- neural tube closure
- positive regulation of transcription, DNA-dependent
- positive regulation of protein ubiquitination
- positive regulation of lymphotoxin A production
- T cell receptor signaling pathway
- positive regulation of mast cell cytokine production
- positive regulation of phosphorylation
- protein homooligomerization
- NIK/NF-kappaB cascade
- adaptive immune response
- B cell apoptotic process
- toll-like receptor signaling pathway
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular defense response
- positive regulation of T cell receptor signaling pathway
- cellular response to mechanical stimulus
- positive regulation of interleukin-8 production
- cellular response to lipopolysaccharide
- innate immune response
- positive regulation of apoptotic process
- immunoglobulin mediated immune response
- T cell apoptotic process
- lipopolysaccharide-mediated signaling pathway
- positive regulation of extrinsic apoptotic signaling pathway
- negative regulation of mature B cell apoptotic process
- positive regulation of interleukin-6 production
- programmed cell death
Cellular Component
Where in the cell the gene product is active
- nucleus
- CBM complex
- perinuclear region of cytoplasm
- cytoplasm
- membrane raft
- cytosol
- polkadots
- macromolecular complex
- cytoplasmic microtubule
- immunological synapse
- lysosome
Molecular Function
What the gene product does at the molecular level
- kinase activator activity
- NF-kappaB binding
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- transcription coactivator activity
- protein kinase B binding
- protease binding
- CARD domain binding
- protein binding, bridging