Bicc1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Acts upstream of or within determination of left/right symmetry; heart development; and kidney development. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and heart and pericardium. Used to study autosomal dominant polycystic kidney disease; autosomal recessive polycystic kidney disease; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in diffuse cystic renal dysplasia. Orthologous to human BICC1 (BicC family RNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bicc1 |
| Official Name | BicC family RNA binding protein 1 [Source:MGI Symbol;Acc:MGI:1933388] |
| Ensembl ID | ENSMUSG00000014329 |
| Bio databases IDs | |
| Aliases | BicC family RNA binding protein 1 |
| Synonyms | BICC, BicC family RNA binding protein 1, bpk, jcpk |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bicc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- K homology (KH) RNA-binding domain, type I
- KH domain
- SAM (Sterile alpha motif )
- SAM domain
- SAM domain (Sterile alpha motif)
- protein binding
- K homology RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- hypertension
- schizophrenia
- susceptibility to cystic renal dysplasia
- chronic kidney disease
- coronary artery disease
- gout
- open-angle glaucoma
- refractive error
- ventricular septal defect
role in cell
- proliferation
- expression in
- cell viability
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bicc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- heart development
- kidney development
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding