Dazl Gene Summary [Mouse]
This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Details
| Type | Protein Coding |
| Official Symbol | Dazl |
| Official Name | deleted in azoospermia-like [Source:MGI Symbol;Acc:MGI:1342328] |
| Ensembl ID | ENSMUSG00000010592 |
| Bio databases IDs | |
| Aliases | deleted in azoospermia-like |
| Synonyms | DAZH, DAZ homolog, DAZL1, DAZLA, Daz-like, deleted in azoospermia-like, LOC682624, SPGYLA, Tpx-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dazl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- translation activator
- DAZ repeat
- protein binding
- identical protein binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- tumorigenesis
- idiopathic male infertility
- lung carcinoma
- lung carcinoma process
- oligozoospermia
- aspermatogenesis
role in cell
- maturation
- expression in
- survival
- induction in
- proliferation
- quantity
- regulation
- development
- abnormal morphology
- 5-hydroxymethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dazl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- germ cell development
- 3'-UTR-mediated mRNA stabilization
- positive regulation of meiosis
- oocyte maturation
- spermatogenesis
- female meiosis II
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
- ribosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- translation activator activity
- mRNA 3'-UTR binding