Stambpl1 Gene Summary [Mouse]
Predicted to enable K63-linked deubiquitinase activity. Predicted to be involved in cellular response to L-leucine and positive regulation of TORC1 signaling. Predicted to be active in endosome and membrane. Is expressed in alimentary system; central nervous system; dorsal root ganglion; limb; and submandibular gland primordium. Orthologous to human STAMBPL1 (STAM binding protein like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stambpl1 |
| Official Name | STAM binding protein like 1 [Source:MGI Symbol;Acc:MGI:1923880] |
| Ensembl ID | ENSMUSG00000024776 |
| Bio databases IDs | |
| Aliases | STAM binding protein like 1 |
| Synonyms | 1700095N21RIK, 8230401J17Rik, ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, STAM binding protein-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stambpl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mpr1p, Pad1p N-terminal (MPN) domains
- Prokaryotic homologs of the JAB domain
- enzyme
- protein binding
- USP8 dimerization domain
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- systemic lupus erythematosus nephritis
regulates
- JNK
- DUSP1
role in cell
- expression in
- phosphorylation in
- cisplatin sensitivity
- response by
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stambpl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to leucine
- proteolysis
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- endosome
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding