Celsr1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Involved in establishment of planar polarity and neural tube closure. Acts upstream of or within several processes, including apical protein localization; morphogenesis of an epithelium; and motor neuron migration. Located in membrane. Is expressed in several structures, including central nervous system; epithelium; primitive streak; renal cortex; and skin. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Celsr1 |
| Official Name | cadherin, EGF LAG seven-pass G-type receptor 1 [Source:MGI Symbol;Acc:MGI:1100883] |
| Ensembl ID | ENSMUSG00000016028 |
| Bio databases IDs | |
| Aliases | cadherin, EGF LAG seven-pass G-type receptor 1 |
| Synonyms | ADGRC1, cadherin EGF LAG seven-pass G-type receptor 1, cadherin, EGF LAG seven-pass G-type receptor 1, CDHF9, crash, Crsh, FMI2, HFMI2, LMPHM9, ME2, Scy |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Celsr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- LamG
- GPCR-Autoproteolysis INducing (GAIN) domain
- Human growth factor-like EGF
- calcium ion binding
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- seven-transmembrane G protein-coupled receptor superfamily
- EGF_CA
- Laminin-type epidermal growth factor-like domai
- Cadherin repeat-like domain
- GPCR proteolysis site, GPS, motif
- laminin G domain
Pathways
Biological processes and signaling networks where the Celsr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphatic malformation 9
- lymphatic malformation
- Alzheimer disease
- chronic lymphocytic leukemia
- androgenic alopecia
- neural tube defect
- self-abusive behavior
- bladder exstrophy
- hemimegalencephaly
role in cell
- cell death
- outgrowth
- migration by
- organization
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Celsr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- establishment of body hair planar orientation
- protein localization involved in establishment of planar polarity
- Rho protein signal transduction
- homophilic cell adhesion
- orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
- planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
- establishment of planar polarity of embryonic epithelium
- neuron migration
- central nervous system development
- regulation of actin cytoskeleton organization
- neural tube closure
- establishment of planar polarity
- apical protein localization
- Wnt receptor signaling pathway, planar cell polarity pathway
- lateral sprouting involved in lung morphogenesis
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- calcium ion binding