Cacnb4 Gene Summary [Mouse]
Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including adult walking behavior; cellular response to leukemia inhibitory factor; and hematopoietic or lymphoid organ development. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse. Is expressed in brain; heart; spinal cord; and urinary system. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and generalized epilepsy. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacnb4 |
| Official Name | calcium channel, voltage-dependent, beta 4 subunit [Source:MGI Symbol;Acc:MGI:103301] |
| Ensembl ID | ENSMUSG00000017412 |
| Bio databases IDs | |
| Aliases | calcium channel, voltage-dependent, beta 4 subunit |
| Synonyms | 3110038O15RIK, CAB4, CACNLB4, Calcium Channel beta4, calcium channel, voltage-dependent, beta 4 subunit, calcium channel, voltage-dependent, β 4 subunit, calcium voltage-gated channel auxiliary subunit beta 4, calcium voltage-gated channel auxiliary subunit β 4, Cchb4, EA5, EIG9, EJM, EJM4, EJM6, lh |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacnb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanylate kinase
- voltage-gated calcium channel
- protein kinase binding
- NK
- high voltage-gated calcium channel
- Voltage gated calcium channel subunit beta domain 4Aa N terminal
- calcium channel beta4 alpha1 binding domain
- protein binding
- ion channel
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Cacnb4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- PKCθ Signaling in T Lymphocytes
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiomyopathy
- COVID-19
- cardiovascular disorder
- hypertension
- atrial fibrillation
- bleeding
- paroxysmal supraventricular tachycardia
- cerebral infarction
- chronic stable angina
- mania
role in cell
- proliferation
- transmembrane potential
- development
- exocytosis
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- vesicles
- cytosol
- cytoplasmic face of plasma membrane
- nuclear speckles
- synapse
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacnb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of light stimulus involved in visual perception
- negative regulation of cell proliferation
- muscle cell development
- gamma-aminobutyric acid secretion
- synaptic transmission
- spleen development
- gamma-aminobutyric acid signaling pathway
- thymus development
- neuromuscular junction development
- adult walking behavior
- cAMP metabolic process
- Peyer's patch development
- calcium ion transmembrane transport
- regulation of synaptic vesicle exocytosis
- negative regulation of G1/S transition of mitotic cell cycle
- neuronal action potential propagation
- T cell receptor signaling pathway
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- voltage-gated calcium channel complex
- cytosol
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- high voltage-gated calcium channel activity
- voltage-gated calcium channel activity