Frmd4b Gene Summary [Mouse]
Acts upstream of or within establishment of epithelial cell polarity. Located in several cellular components, including adherens junction; bicellular tight junction; and ruffle. Is expressed in several structures, including alimentary system; gallbladder; genitourinary system; nervous system; and vascular system. Orthologous to human FRMD4B (FERM domain containing 4B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frmd4b |
| Official Name | FERM domain containing 4B [Source:MGI Symbol;Acc:MGI:2141794] |
| Ensembl ID | ENSMUSG00000030064 |
| Bio databases IDs | |
| Aliases | FERM domain containing 4B |
| Synonyms | 6030440G05RIK, C87375, FERM domain containing 4B, GOBLIN, GRSP1, Nitzin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Frmd4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytohesin Ubiquitin Protein Inducing Domain
- FERM central domain
- Band 4.1 homologues
- RXXs motif
- Ubl1_cv_Nsp3_N-like
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- sXXN motif
- FERM domain B-lobe
- FERM C-terminal PH-like domain
- FERM N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myelodysplastic syndrome
- prostate cancer
- schizophrenia
- squamous cell cancer
- epithelial cancer
- Alzheimer disease
- Huntington disease
- insomnia
- cardiomyopathy
- breast cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- tight junctions
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Frmd4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of epithelial cell polarity
Cellular Component
Where in the cell the gene product is active
- adherens junction
- tight junction
- extracellular space
- cytoskeleton
- cytoplasm
- ruffle