Tamalin Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity; identical protein binding activity; and small GTPase binding activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within signal transduction. Located in plasma membrane. Is active in glutamatergic synapse. Orthologous to human TAMALIN (trafficking regulator and scaffold protein tamalin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tamalin |
| Official Name | trafficking regulator and scaffold protein tamalin [Source:MGI Symbol;Acc:MGI:1860303] |
| Ensembl ID | ENSMUSG00000000531 |
| Bio databases IDs | |
| Aliases | trafficking regulator and scaffold protein tamalin |
| Synonyms | GRASP, LOC102556412, trafficking regulator and scaffold protein tamalin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tamalin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine rich domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- leucine rich domain
- Cytohesin binding domain
- canonical PDZ domain
- enzyme binding
- leucine zipper domain
- protein binding
- PDZ domain
- alanine-proline rich region
- proline rich domain
- identical protein binding
- PDZ-domain binding
- PDZ binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast adenocarcinoma
- diabetic peripheral neuropathy
- epileptic seizure
role in cell
- proliferation
- binding in
- adhesion
- excitatory postsynaptic potential
- differentiation
- sprouting
- long-term potentiation
- arborization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- perinuclear region
- cellular membrane
- cell cortex
- perinuclear space
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tamalin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- perinuclear region of cytoplasm
- postsynaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- PDZ domain binding
- small GTPase binding