Ddx11 Gene Summary [Mouse]
Predicted to enable several functions, including 5'-3' DNA helicase activity; DNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in several processes, including cellular response to bleomycin; cellular response to cisplatin; and positive regulation of nucleobase-containing compound metabolic process. Predicted to be located in several cellular components, including extracellular exosome; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in nucleus. Is expressed in several structures, including cerebral cortex; extraembryonic component; and placenta. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx11 |
| Official Name | DEAD/H box helicase 11 [Source:MGI Symbol;Acc:MGI:2443590] |
| Ensembl ID | ENSMUSG00000035842 |
| Bio databases IDs | |
| Aliases | DEAD/H box helicase 11 |
| Synonyms | 4732462I11RIK, CHL1, CHLR1, DEAD/H-box helicase 11, essa15a, KRG2, WABS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA repair helicase (rad3)
- helicase
- helicase superfamily c-terminal domain
- DNA replication origin binding
- chromatin binding
- enzyme
- protein binding
- DNA dependent ATPase
- single-stranded RNA binding
- RNA dependent ATPase
- DNA binding
- DNA helicase
- helicase C-terminal domain
- triplex DNA binding
- single-stranded DNA binding
- double-stranded DNA binding
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- heart failure
- Warsaw breakage syndrome
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- growth failure
- hereditary disorder
role in cell
- binding
- apoptosis
- damage in
- cell viability
- cohesion
- DNA damage response
- response by
- cohesion in
- aneuploidy
- processing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- midbody
- nucleoplasm
- nucleoli
- spindle pole
- chromatin
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- cellular response to cisplatin
- establishment of sister chromatid cohesion
- sister chromatid cohesion
- positive regulation of chromatin binding
- response to DNA damage stimulus
- negative regulation of protein binding
- positive regulation of sister chromatid cohesion
- DNA duplex unwinding
- cellular response to hydroxyurea
- replication fork processing
- positive regulation of endodeoxyribonuclease activity
- positive regulation of double-strand break repair
Cellular Component
Where in the cell the gene product is active
- Ctf18 RFC-like complex
- nucleus
- centrosome
- extracellular vesicular exosome
- cytoplasm
- spindle pole
- mitotic cohesin complex
- midbody
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA-dependent ATPase activity
- RNA-dependent ATPase activity
- double-stranded DNA binding
- helicase activity
- chromatin binding
- 5'-3' DNA helicase activity
- single-stranded DNA binding
- ATP binding
- DNA replication origin binding
- DNA binding
- DNA helicase activity
- protein binding
- G-quadruplex DNA binding
- metal ion binding
- triplex DNA binding
- single-stranded RNA binding
- 4 iron, 4 sulfur cluster binding