Smpdl3a Gene Summary [Mouse]
Predicted to enable phosphoric diester hydrolase activity and zinc ion binding activity. Involved in negative regulation of cGAS/STING signaling pathway. Located in extracellular space. Is expressed in cerebral cortex ventricular layer; ovary; and ureteric tip. Orthologous to human SMPDL3A (sphingomyelin phosphodiesterase acid like 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smpdl3a |
| Official Name | sphingomyelin phosphodiesterase, acid-like 3A [Source:MGI Symbol;Acc:MGI:1931437] |
| Ensembl ID | ENSMUSG00000019872 |
| Bio databases IDs | |
| Aliases | sphingomyelin phosphodiesterase, acid-like 3A |
| Synonyms | 0610010C24Rik, ASM3A, ASML3, ASML3A, Asm Like Phosphodiesterase 3a, sphingomyelin phosphodiesterase acid like 3A, sphingomyelin phosphodiesterase, acid-like 3A, yR36GH4.1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smpdl3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid sphingomyelin phosphodiesterase C-terminal region
- zinc ion binding
- enzyme
- protein binding
- metallophosphatase superfamily, metallophosphatase domain
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the Smpdl3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smpdl3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside triphosphate catabolic process
- sphingomyelin catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- zinc ion binding
- protein binding
- sphingomyelin phosphodiesterase activity
- phosphoric diester hydrolase activity