Anapc1 Gene Summary [Mouse]
Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein polyubiquitination. Located in nucleus. Is expressed in brain; cerebellum; and cerebral cortex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anapc1 |
| Official Name | anaphase promoting complex subunit 1 [Source:MGI Symbol;Acc:MGI:103097] |
| Ensembl ID | ENSMUSG00000014355 |
| Bio databases IDs | |
| Aliases | anaphase promoting complex subunit 1 |
| Synonyms | 2610021O03Rik, anaphase promoting complex subunit 1, APC1, LOC100134261, LOC100653327, LOC285069, MCPR, TSG24 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Anapc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 1 N-terminal
- Anaphase-promoting complex subunit 1 WD40 beta-propeller domain
- Anaphase-promoting complex sub unit 1 C-terminal domain
- protein binding
- Proteasome/cyclosome repeat
- Anaphase-promoting complex subunit 1 middle domain
Pathways
Biological processes and signaling networks where the Anapc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Rothmund-Thomson syndrome type 1
- otosclerosis
- osteoporosis
- eczema
- allergy
- allergic sensitization
- open-angle glaucoma
role in cell
- expression in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- vesicles
- centrosome
- cytosol
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Anapc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of meiotic cell cycle
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- mitotic metaphase/anaphase transition
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- anaphase-promoting complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- binding, bridging