Clspn Gene Summary [Mouse]
Predicted to enable DNA secondary structure binding activity and anaphase-promoting complex binding activity. Predicted to be involved in activation of protein kinase activity; mitotic G2/M transition checkpoint; and peptidyl-serine phosphorylation. Predicted to be located in Golgi apparatus and nucleoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; endocrine gland; genitourinary system; and immune system. Orthologous to human CLSPN (claspin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clspn |
| Official Name | claspin [Source:MGI Symbol;Acc:MGI:2445153] |
| Ensembl ID | ENSMUSG00000042489 |
| Bio databases IDs | |
| Aliases | claspin |
| Synonyms | B130025E01, C85083, claspin, E130314M08RIK, LOC100912611 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clspn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DSGxxS motif
- binding protein
- DNA binding domain
- DNA secondary structure binding
- protein binding
Pathways
Biological processes and signaling networks where the Clspn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- colon adenocarcinoma
- transitional cell bladder cancer
- squamous cell lung cancer
- lung squamous cell carcinoma
- rectum cancer
- renal clear cell adenocarcinoma
- papillary renal cell carcinoma
role in cell
- growth
- phosphorylation in
- proliferation
- DNA damage response
- cell cycle progression
- G2/M phase
- formation
- progression
- cell death
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin fraction
- Golgi Apparatus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clspn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA damage checkpoint
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA replication checkpoint
- activation of protein kinase activity
- peptidyl-serine phosphorylation
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- nucleus
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- DNA secondary structure binding
- anaphase-promoting complex binding