Tns3 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor adaptor activity. Involved in positive regulation of guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including bone resorption; podosome assembly; and regulation of small GTPase mediated signal transduction. Located in podosome. Is expressed in several structures, including craniocervical region bone; foot mesenchyme; reproductive system; spleen primordium; and tail. Orthologous to human TNS3 (tensin 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tns3 |
| Official Name | tensin 3 [Source:MGI Symbol;Acc:MGI:2443012] |
| Ensembl ID | ENSMUSG00000020422 |
| Bio databases IDs | |
| Aliases | tensin 3 |
| Synonyms | BC023928, F830010I22Rik, LOC102723974, RGD1564174, RGD1564930, Similar to tensin-like sh2 domain containing 1, TEM6, TENS1, TENS3, tensin 3, TSN3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tns3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- actin-binding domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- C2 domain of PTEN tumour-suppressor protein
- phosphatase
- guanyl-nucleotide exchange factor adaptor
- Src homology 2 (SH2) domain
- protein binding
- Pleckstrin homology-like domain
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-small cell lung cancer
- prostatic carcinoma
- prostate cancer
- epithelial basal cell carcinoma
- colorectal cancer
- non-small cell lung carcinoma
- coronary artery disease
- dementia
- Kawasaki disease
role in cell
- binding in
- activation in
- growth
- proliferation
- migration
- assembly
- formation
- formation in
- interaction in
- fibrillogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- focal adhesions
- podosomes
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tns3 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytosol
- cell projection
- podosome
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein binding