Map3k3 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development and positive regulation of p38MAPK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including early conceptus; heart; and metanephros. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k3 |
| Official Name | mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874] |
| Ensembl ID | ENSMUSG00000020700 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 3 |
| Synonyms | CCM5, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3, mKIAA4031 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map3k3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- regulatory domain
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- MAP kinase kinase kinase
- PB1
- Phox and Bem1 domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- active site
- basic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Map3k3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- ERK5 Signaling
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Natural Killer Cell Signaling
- NF-κB Signaling
- NGF Signaling
- Nur77 Signaling in T Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- SAPK/JNK Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- verrucous venous malformation
- migraines
- psoriatic arthritis
role in cell
- production in
- expression in
- binding in
- activation in
- proliferation
- phosphorylation in
- quantity
- apoptosis
- differentiation
- inflammation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map3k3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- blood vessel development
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of cell proliferation in bone marrow
- protein autophosphorylation
- positive regulation of cell migration involved in sprouting angiogenesis
- intracellular signal transduction
- negative regulation of cellular senescence
- positive regulation of p38MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity