Ddx42 Gene Summary [Mouse]
Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in U2-type prespliceosome assembly; protein localization; and regulation of apoptotic process. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type prespliceosome. Predicted to be active in nucleus. Orthologous to human DDX42 (DEAD-box helicase 42). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx42 |
| Official Name | DEAD box helicase 42 [Source:MGI Symbol;Acc:MGI:1919297] |
| Ensembl ID | ENSMUSG00000020705 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 42 |
| Synonyms | 1810047H21Rik, B430002H05Rik, DDX42P, DEAD-box helicase 42, RHELP, RNA helicase, RNAHP, SF3b125, SF3B8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- CRISPR-associated helicase Cas3
- Helicase conserved C-terminal domain
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
phenotypes
- preweaning lethality complete penetrance
- abnormal chorion morphology
- abnormal trophoblast layer morphology
- embryonic lethality during organogenesis complete penetrance
role in cell
- cell viability
- apoptosis
- processing in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx42 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization
- regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- membrane
- Cajal body
- cytosol
- U2-type prespliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity