Fkbp3 Gene Summary [Mouse]

Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity and RNA polymerase II CTD heptapeptide repeat P6 isomerase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human FKBP3 (FKBP prolyl isomerase 3). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Retained Intron
Official Symbol
Fkbp3
Official Name
FK506 binding protein 3 [Source:MGI Symbol;Acc:MGI:1353460]
Ensembl ID
ENSMUSG00000020949
Bio databases IDs NCBI: 30795 Ensembl: ENSMUSG00000020949
Aliases FK506 binding protein 3
Synonyms FK506 binding protein 3, FKBP15, FKBP-25, FKBP prolyl isomerase 3, PPIase
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fkbp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • FKBP-type peptidyl-prolyl cis-trans isomerase
  • signaling receptor activity
  • peptidylprolyl isomerase
  • FK506 binding
  • basic tilted helix bundle (BTHB) domain
  • enzyme
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • lymphoma
  • lymphomagenesis
  • hypertensive renal disease
regulated by
  • camptothecin
  • CD3 (complex)
  • TP53
  • BAG3
  • PARP2
  • progesterone
  • E2F1
  • CK2
  • uranyl nitrate
  • rotenone
role in cell
  • morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fkbp3 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • nucleus

Molecular Function

What the gene product does at the molecular level
  • peptidyl-prolyl cis-trans isomerase activity
  • RNA binding
  • protein binding
  • FK506 binding
  • signaling receptor activity

Gene-Specific Assays for Results You Can Trust

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