Apbb3 Gene Summary [Mouse]
Predicted to enable amyloid-beta binding activity; low-density lipoprotein particle receptor binding activity; and molecular adaptor activity. Predicted to be involved in negative regulation of cell cycle phase transition; negative regulation of transcription by RNA polymerase II; and positive regulation of protein secretion. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including actin cytoskeleton; cytosol; and nuclear body. Predicted to be active in cytoplasm and nucleus. Orthologous to human APBB3 (amyloid beta precursor protein binding family B member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apbb3 |
| Official Name | amyloid beta (A4) precursor protein-binding, family B, member 3 [Source:MGI Symbol;Acc:MGI:108404] |
| Ensembl ID | ENSMUSG00000117679 |
| Bio databases IDs | |
| Aliases | amyloid beta (A4) precursor protein-binding, family B, member 3 |
| Synonyms | amyloid beta precursor protein binding family B member 3, amyloid β precursor protein binding family B member 3, FE65L2, LOC100505798, Rirl2, SRA, TR2S |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apbb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain with 2 conserved Trp (W) residues
- WW
- protein binding
- low-density lipoprotein receptor binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- beta-amyloid binding
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- preeclampsia
role in cell
- activation in
- apoptosis
- cell cycle progression
- production in
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- actin cytoskeleton
- Nucleus
- cytosol
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apbb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- positive regulation of protein secretion
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- membrane
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- low-density lipoprotein particle receptor binding
- transcription factor binding
- beta-amyloid binding