Pygl Gene Summary [Mouse]
Enables glycogen phosphorylase activity. Involved in glycogen catabolic process. Acts upstream of or within necroptotic process and response to bacterium. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; cranium; sensory organ; and urinary system. Used to study glycogen storage disease VI. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGL (glycogen phosphorylase L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pygl |
| Official Name | liver glycogen phosphorylase [Source:MGI Symbol;Acc:MGI:97829] |
| Ensembl ID | ENSMUSG00000021069 |
| Bio databases IDs | |
| Aliases | liver glycogen phosphorylase |
| Synonyms | glycogen phosphorylase L, Gp, GSD6, Hepatic isoform of glycogen phosphorylase, Hepatic isoform of gp, liver glycogen phosphorylase, PHOSPHORYLASE B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pygl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- vitamin binding
- Carbohydrate phosphorylase
- ATP binding
- glucose binding
- glycogen/starch/alpha-glucan phosphorylases
- enzyme
- protein binding
- identical protein binding
- phosphorylation site
- AMP binding
- binding protein
- serine phosphorylation site
- carbohydrate binding
- phosphorylase
- glycogen phosphorylase
Pathways
Biological processes and signaling networks where the Pygl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
- glycogen storage disease type VI
- ischemic stroke
- organismal death
- acute lymphoblastic leukemia
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- metastasis
- androgenic alopecia
role in cell
- migration
- expression in
- accumulation in
- glycolysis in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pygl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- glycogen metabolic process
- necroptosis
- glucose homeostasis
- glycogen catabolic process
- 5-phosphoribose 1-diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycogen phosphorylase activity
- glucose binding
- ATP binding
- pyridoxal phosphate binding
- identical protein binding
- AMP binding
- protein binding
- purine base binding
- bile acid binding
- vitamin binding