Asb2 Gene Summary [Mouse]
Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Involved in several processes, including heart development; podosome assembly; and skeletal muscle atrophy. Acts upstream of or within skeletal muscle cell differentiation. Located in Z disc. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart; and musculature. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asb2 |
| Official Name | ankyrin repeat and SOCS box-containing 2 [Source:MGI Symbol;Acc:MGI:1929743] |
| Ensembl ID | ENSMUSG00000021200 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and SOCS box-containing 2 |
| Synonyms | 1110008E15Rik, ankyrin repeat and SOCS box-containing 2, LOC100909439 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- elongin B/C binding domain
- transcription regulator
- Ankyrin repeats (many copies)
- BC-box
- ubiquitin protein ligase activity
- Ankyrin repeats (3 copies)
- SOCS
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- atrial fibrillation
- dilated cardiomyopathy
- colon cancer
- epithelial cancer
- septic shock
- Alzheimer disease
- prostate cancer
- acute myeloid leukemia
- astrocytoma
role in cell
- expression in
- migration
- differentiation
- development
- formation
- organization
- degradation by
- migration by
- degradation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- skeletal muscle cell differentiation
- signal transduction
- cardiac muscle cell development
- heart looping
- actin cytoskeleton organization
- cardiac muscle cell differentiation
- intracellular signal transduction
- podosome assembly
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- Z disc
- ubiquitin ligase complex
- stress fiber
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding