Mtmr6 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; and ruffle membrane. Predicted to be active in cytoplasm and nuclear envelope. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR6 (myotubularin related protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtmr6 |
| Official Name | myotubularin related protein 6 [Source:MGI Symbol;Acc:MGI:2145637] |
| Ensembl ID | ENSMUSG00000021987 |
| Bio databases IDs | |
| Aliases | myotubularin related protein 6 |
| Synonyms | 4022440C11Rik, Gm38641, myotubularin related protein 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtmr6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-3-phosphatase
- phosphatase
- Myotubularin-like phosphatase domain
- protein binding
- Pleckstrin homology-like domain
- PTP_DSP_cys
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell center
- pericentrosomal domain of the intermediate compartment
- perinuclear Golgi regions
- perinuclear region
- Endoplasmic Reticulum
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtmr6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
- phosphatidylinositol biosynthetic process
- endocytosis
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- ruffle membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- phosphatidylinositol-3-phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity