Thoc1 Gene Summary [Mouse]
Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in brain; early conceptus; and embryo. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 86. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thoc1 |
| Official Name | THO complex 1 [Source:MGI Symbol;Acc:MGI:1919668] |
| Ensembl ID | ENSMUSG00000024287 |
| Bio databases IDs | |
| Aliases | THO complex 1 |
| Synonyms | 3110002N20Rik, DFNA86, HPR1, LRRGT00070, NMP-84, P84, P84N5, tho1, THO complex 1, THO complex subunit 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thoc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- transcription regulator
- THO complex subunit 1 transcription elongation factor
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian neoplasm
- ovarian neoplasia
- mammary neoplasm
- major depression
- autosomal dominant deafness type 86
- chromosomal instability
- colon neoplasm
- colorectal neoplasia
- lung neoplasm
role in cell
- apoptosis
- growth
- proliferation
- cell viability
- G2/M phase transition
- survival
- formation in
- accumulation in
- acetylation in
- appearance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intranuclear region
- spliceosomes
- nucleoplasm
- nuclear speckles
- nuclear matrix
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thoc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA splicing
- signal transduction
- apoptotic process
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- cytoplasm
- nuclear speck
- nuclear matrix
- THO complex
- transcription export complex
- THO complex part of transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding