Osr2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic limb morphogenesis; kidney development; and regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic skeletal system morphogenesis and positive regulation of stem cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human OSR2 (odd-skipped related transciption factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Osr2 |
| Official Name | odd-skipped related 2 [Source:MGI Symbol;Acc:MGI:1930813] |
| Ensembl ID | ENSMUSG00000022330 |
| Bio databases IDs | |
| Aliases | odd-skipped related 2 |
| Synonyms | 5430409I15Rik, odd-skipped related 2, odd-skipped related transciption factor 2, Osr2A, Osr2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Osr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometrial cancer
- cleft palate syndrome
- diabetic nephropathy
- early missed abortion
- endometriosis
role in cell
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Osr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- head development
- embryo development ending in birth or egg hatching
- positive regulation of cell proliferation
- palate development
- bone morphogenesis
- chondrocyte differentiation
- middle ear morphogenesis
- odontogenesis
- positive regulation of transcription from RNA polymerase II promoter
- embryonic digit morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- mesonephros development
- stem cell proliferation
- embryonic forelimb morphogenesis
- positive regulation of epithelial cell proliferation
- positive regulation of bone mineralization
- embryonic hindlimb morphogenesis
- embryonic skeletal limb joint morphogenesis
- embryonic skeletal joint morphogenesis
- embryonic skeletal system morphogenesis
- eyelid development in camera-type eye
- regulation of transcription from RNA polymerase II promoter
- urogenital system development
- metanephros development
- embryonic skeletal joint development
- positive regulation of stem cell proliferation
- positive regulation of gene expression
- osteoblast proliferation
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity