Gfus Gene Summary [Mouse]
Enables GDP-L-fucose synthase activity and isomerase activity. Involved in 'de novo' GDP-L-fucose biosynthetic process. Acts upstream of or within T cell mediated cytotoxicity. Is active in cytosol. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Gfus |
| Official Name | GDP-L-fucose synthase [Source:MGI Symbol;Acc:MGI:98857] |
| Ensembl ID | ENSMUSG00000022570 |
| Bio databases IDs | |
| Aliases | GDP-L-fucose synthase |
| Synonyms | FX, GDP-L-fucose synthase, P35B, SDR4E1, TSTA3, Tstap35b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gfus often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- electron carrier
- 3-beta hydroxysteroid dehydrogenase/isomerase family
- GDP-L-fucose synthase
- NAD dependent epimerase/dehydratase family
- GDP-4-dehydro-D-rhamnose reductase
- isomerase
- GDPmannose 3,5-epimerase
- enzyme
- protein binding
- identical protein binding
- GDP-mannose 4,6 dehydratase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diarrhea
- pulmonary fibrosis
- HER2 negative hormone receptor negative breast cancer
- infertility condition
role in cell
- expression in
- number
- migration
- interaction
- adhesion
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gfus gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 'de novo' GDP-L-fucose biosynthetic process
- GDP-mannose metabolic process
- positive regulation of endothelial cell migration
- leukocyte cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- GDP-mannose 3,5-epimerase activity
- identical protein binding
- protein binding
- electron carrier activity
- GDP-4-dehydro-D-rhamnose reductase activity
- GDP-L-fucose synthase activity