Larp4 Gene Summary [Mouse]

Predicted to enable mRNA 3'-UTR binding activity and poly(A) binding activity. Predicted to be involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP4 (La ribonucleoprotein 4). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Larp4
Official Name
La ribonucleoprotein domain family, member 4 [Source:MGI Symbol;Acc:MGI:2443114]
Ensembl ID
ENSMUSG00000023025
Bio databases IDs NCBI: 207214 Ensembl: ENSMUSG00000023025
Aliases La ribonucleoprotein domain family, member 4
Synonyms DXErtd793, DXErtd793e, La ribonucleoprotein 4, LOC681258, PP13296
Species
Mouse, Mus musculus
OrthologiesHuman

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Larp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA recognition motif (RRM) superfamily
  • La domain
  • mRNA 3' UTR binding
  • RNA recognition motif
  • poly(A) binding protein
  • protein binding
  • LA motif RNA-binding domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Alzheimer disease
regulated by
  • tetradecanoylphorbol acetate
  • lipopolysaccharide
  • LAMA4
  • ANGPT2
  • topotecan
  • Gstp1 (includes others)
role in cell
  • proliferation
  • migration
  • organization
  • morphogenesis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • ribosome
  • cytosol
  • stress granule

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Larp4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • posttranscriptional regulation of gene expression
  • positive regulation of translation
  • cytoskeleton organization
  • regulation of cell morphogenesis
  • translation

Cellular Component

Where in the cell the gene product is active
  • cytoplasmic stress granule
  • cytosolic small ribosomal subunit
  • membrane
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • protein binding
  • poly(A) RNA binding
  • mRNA 3'-UTR binding

Gene-Specific Assays for Results You Can Trust

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