Tenm4 Gene Summary [Mouse]
Enables protein homodimerization activity. Involved in several processes, including central nervous system myelin formation; positive regulation of gastrulation; and regulation of nervous system development. Acts upstream of or within cardiac cell fate specification; cardiac muscle cell proliferation; and gastrulation with mouth forming second. Located in several cellular components, including neuron projection; nucleus; and plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; future brain; somite; and upper leg. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tenm4 |
| Official Name | teneurin transmembrane protein 4 [Source:MGI Symbol;Acc:MGI:2447063] |
| Ensembl ID | ENSMUSG00000048078 |
| Bio databases IDs | |
| Aliases | teneurin transmembrane protein 4 |
| Synonyms | Doc4, ELM2, ETM5, l(7)-3Rn, l7Rn3, mKIAA1302, ODZ4, R75022, TEN4, teneurin transmembrane protein 4, TNM4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tenm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RHS repeat-associated core domain
- Keratin, high sulfur B2 protein
- protein binding
- NHL repeat unit of beta-propeller proteins
- identical protein binding
- Family of unknown function (DUF5885)
- EGF_CA
- GHH signature containing HNH/Endo VII superfamily nuclease toxin
- Delta serrate ligand
- YD repeat (two copies)
- protein homodimerization
- Teneurin Intracellular Region
- RHS Repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- prostate cancer
- hereditary essential tremor type 5
- insomnia
- lung carcinoma
- lung carcinoma process
- metabolic syndrome X
- late-onset Alzheimer disease
- schizophrenia
role in cell
- differentiation
- phosphorylation in
- formation
- formation in
- activation in
- development
- proliferation by
- length
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- filopodia-like projection
- Cytoplasm
- cell surface
- Nucleus
- growth cone
- neurites
- nerve ending
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tenm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- gastrulation with mouth forming second
- positive regulation of gastrulation
- heterophilic cell-cell adhesion
- central nervous system myelin formation
- regulation of myelination
- cardiac cell fate specification
- neuron development
- cardiac muscle cell proliferation
- positive regulation of myelination
- positive regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- cell adhesion molecule binding