Abcg4 Gene Summary [Mouse]
Enables ABC-type sterol transporter activity. Involved in several processes, including cholesterol efflux; cholesterol homeostasis; and positive regulation of cholesterol biosynthetic process. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in endosome membrane. Is expressed in several structures, including genitourinary system; immune system; liver; nervous system; and sensory organ. Orthologous to human ABCG4 (ATP binding cassette subfamily G member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Abcg4 |
| Official Name | ATP binding cassette subfamily G member 4 [Source:MGI Symbol;Acc:MGI:1890594] |
| Ensembl ID | ENSMUSG00000032131 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily G member 4 |
| Synonyms | 6430517O04Rik, ATP binding cassette subfamily G member 4, WHITE2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ABC-2 type transporter
- ATPase activity, coupled to transmembrane movement of substances
- FeS assembly ATPase SufC
- The Eye Pigment Precursor Transporter (EPP) Family protein
- phosphonate ABC transporter, ATP-binding protein
- protein binding
- nitrate transport ATP-binding subunits C and D
- identical protein binding
- ATPase
- heme ABC exporter, ATP-binding protein CcmA
- urea ABC transporter, ATP-binding protein UrtE
- lipid transporter
- cobalt transport protein ATP-binding subunit
- energy-coupling factor transporter ATPase
- protein homodimerization
- ABC transporter
- thiamine ABC transporter, ATP-binding protein
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Abcg4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomes
- endosomal membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abcg4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- positive regulation of cholesterol efflux
- cellular response to high density lipoprotein particle stimulus
- regulation of transcription, DNA-dependent
- positive regulation of cholesterol biosynthetic process
- cholesterol efflux
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- sterol-transporting ATPase activity
- identical protein binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity