Lims2 Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including cell-cell junction organization; negative regulation of cell population proliferation; and positive regulation of integrin-mediated signaling pathway. Located in focal adhesion. Is expressed in several structures, including bladder; early conceptus; nervous system; oocyte; and urethra of male. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to human LIMS2 (LIM zinc finger domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lims2 |
| Official Name | LIM and senescent cell antigen like domains 2 [Source:MGI Symbol;Acc:MGI:2385067] |
| Ensembl ID | ENSMUSG00000024395 |
| Bio databases IDs | |
| Aliases | LIM and senescent cell antigen like domains 2 |
| Synonyms | LGMD2W, LIM and senescent cell antigen like domains 2, LIM zinc finger domain containing 2, MDRCMTT, PINCH-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lims2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Pathways
Biological processes and signaling networks where the Lims2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- colorectal cancer
- cutaneous melanoma
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- limb-girdle muscular dystrophy type 2W
- cutaneous melanoma cancer
- limb-girdle muscular dystrophy type 2
- dilated cardiomyopathy
- cardiac fibrosis
role in cell
- migration
- disruption
- apoptosis
- proliferation
- size
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lims2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- integrin-mediated signaling pathway
- negative regulation of apoptotic process
- neural precursor cell proliferation
- negative regulation of neural precursor cell proliferation
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of integrin-mediated signaling pathway
- cell-cell junction organization
- negative regulation of hepatocyte proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell-cell junction
- focal adhesion
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding