Spink1 Gene Summary [Mouse]
Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of protein metabolic process; regulation of calcium ion transport; and sperm capacitation. Located in extracellular space. Is expressed in several structures, including embryo ectoderm; genitourinary system; gut; liver; and yolk sac. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spink1 |
| Official Name | serine peptidase inhibitor, Kazal type 1 [Source:MGI Symbol;Acc:MGI:106202] |
| Ensembl ID | ENSMUSG00000024503 |
| Bio databases IDs | |
| Aliases | serine peptidase inhibitor, Kazal type 1 |
| Synonyms | LOC266602, p12, PCTT, PSTI, PSTI1, Psti-ii, serine peptidase inhibitor Kazal type 1, serine peptidase inhibitor, Kazal type 1, Serine Protease Inhibitor, Kazal Type 1, SPINK3, TATI, TCP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spink1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- protease inhibitor
- serine protease inhibitor activity
- protein binding
- KAZAL_FS
Pathways
Biological processes and signaling networks where the Spink1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hereditary chronic pancreatitis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- systemic lupus erythematosus
- renal cell cancer
- alcoholic chronic pancreatitis
- diabetes mellitus
- chronic pancreatitis
role in cell
- phosphorylation in
- expression in
- proliferation
- colony formation
- accumulation
- abnormal morphology
- autophagy in
- capacitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spink1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of acrosome reaction
- nitric oxide mediated signal transduction
- positive regulation of peptide hormone secretion
- positive regulation of pancreatic juice secretion
- negative regulation of calcium ion import
- elevation of cytosolic calcium ion concentration
- response to ethanol
- sperm capacitation
- cellular response to peptide hormone stimulus
- response to nutrient levels
- positive regulation of epithelial cell proliferation
- regulation of store-operated calcium entry
- negative regulation of peptidyl-tyrosine phosphorylation
- negative regulation of nitric oxide mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- protein binding