Mlana Gene Summary [Mouse]
Predicted to be located in Golgi apparatus. Predicted to be active in endoplasmic reticulum membrane; melanosome; and trans-Golgi network. Is expressed in dermis; eye; and pigmented retinal epithelium. Orthologous to human MLANA (melan-A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mlana |
| Official Name | melan-A [Source:MGI Symbol;Acc:MGI:108454] |
| Ensembl ID | ENSMUSG00000024806 |
| Bio databases IDs | |
| Aliases | melan-A |
| Synonyms | A930034P04Rik, MART-1, Melan-A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlana often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein melan-A
- protein binding
- cytosolic tail domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- melanoma
- melanoma cancer
- adrenal cortex neoplasm
- senile lentigo
- adrenal cortex carcinoma
- adrenocortical carcinoma
role in cell
- production in
- maturation
- activation
- quantity
- expansion
- lysis
- clustering
- cytotoxicity
- maturation in
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum fraction
- endosomal fractions
- Golgi-enriched fraction
- Cytoplasm
- perinuclear region
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- trans Golgi network
- melanosomes
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlana gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- trans-Golgi network
- melanosome
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding