Pold4 Gene Summary [Mouse]
Predicted to contribute to DNA-directed DNA polymerase activity. Acts upstream of or within positive regulation of endothelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; cranium; genitourinary system; liver; and respiratory system. Orthologous to human POLD4 (DNA polymerase delta 4, accessory subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pold4 |
| Official Name | polymerase (DNA-directed), delta 4 [Source:MGI Symbol;Acc:MGI:1916995] |
| Ensembl ID | ENSMUSG00000024854 |
| Bio databases IDs | |
| Aliases | polymerase (DNA-directed), delta 4 |
| Synonyms | 2410012M21Rik, DNA polymerase delta 4, accessory subunit, DNA polymerase δ 4, accessory subunit, p12, POLDS, POLO2, polymerase (DNA-directed), delta 4, polymerase (DNA-directed), δ 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pold4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PCNA-interacting protein box
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Pold4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- non-small cell lung carcinoma
- small cell lung carcinoma
- small cell lung cancer
- colon cancer
role in cell
- proliferation
- growth
- cell cycle progression
- length
- G2/M phase
- lipotoxicity in
- induction in
- end-to-end fusion in
- end-to-end fusion
- chromosomal aberration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pold4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication
- positive regulation of endothelial cell proliferation
- DNA synthesis involved in DNA repair
Cellular Component
Where in the cell the gene product is active
- delta DNA polymerase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed DNA polymerase activity
- protein binding