Pold2 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Involved in DNA biosynthetic process. Part of delta DNA polymerase complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and hemolymphoid system. Orthologous to human POLD2 (DNA polymerase delta 2, accessory subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pold2 |
| Official Name | polymerase (DNA directed), delta 2, regulatory subunit [Source:MGI Symbol;Acc:MGI:1097163] |
| Ensembl ID | ENSMUSG00000020471 |
| Bio databases IDs | |
| Aliases | polymerase (DNA directed), delta 2, regulatory subunit |
| Synonyms | DNA polymerase delta 2, accessory subunit, DNA polymerase δ 2, accessory subunit, p50, po1D2, polymerase (DNA directed), delta 2, regulatory subunit, Polymerase (DNA directed), delta 2, regulatory subunit 50kDa, polymerase (DNA directed), δ 2, regulatory subunit, Polymerase (DNA directed), δ 2, regulatory subunit 50kDa |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pold2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA polymerase delta subunit OB-fold domain
- DNA-directed DNA polymerase
- DNA polymerase alpha/epsilon subunit B
- enzyme
- protein binding
- metallophosphatase superfamily, metallophosphatase domain
Pathways
Biological processes and signaling networks where the Pold2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleolar fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pold2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA strand elongation involved in DNA replication
- DNA replication
- DNA-dependent DNA replication
- DNA biosynthetic process
- error-prone translesion synthesis
Cellular Component
Where in the cell the gene product is active
- delta DNA polymerase complex
- nucleus
- zeta DNA polymerase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding