Peli3 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; protein K63-linked ubiquitination; and regulation of signal transduction. Is expressed in eye; ileum; male reproductive gland or organ; and nervous system. Orthologous to human PELI3 (pellino E3 ubiquitin protein ligase family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Peli3 |
| Official Name | pellino 3 [Source:MGI Symbol;Acc:MGI:1924963] |
| Ensembl ID | ENSMUSG00000024901 |
| Bio databases IDs | |
| Aliases | pellino 3 |
| Synonyms | 6030441F14RIK, A930011L17, BC028931, PELLINO3, pellino E3 ubiquitin protein ligase family member 3, RGD1305989 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Peli3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- enzyme
- protein binding
- Pellino
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insulin resistance
- centrilobular necrosis
- obesity
- pervasive developmental disorder
- insomnia
- neurological disorder
- infection by Picornaviridae
role in cell
- degradation in
- activation in
- phosphorylation in
- cellular infiltration by
- hyperphosphorylation in
- function
- stabilization in
- K48 polyubiquitination in
- ubiquitination in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Peli3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- negative regulation of tumor necrosis factor-mediated signaling pathway
- regulation of Toll signaling pathway
- protein K63-linked ubiquitination
- negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding