PELI3 Gene Summary [Human]
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Details
| Type | Protein Coding |
| Official Symbol | PELI3 |
| Official Name | pellino E3 ubiquitin protein ligase family member 3 [Source:HGNC Symbol;Acc:HGNC:30010] |
| Ensembl ID | ENSG00000174516 |
| Bio databases IDs | |
| Aliases | pellino E3 ubiquitin protein ligase family member 3 |
| Synonyms | 6030441F14RIK, A930011L17, BC028931, PELLINO3, pellino E3 ubiquitin protein ligase family member 3, RGD1305989 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PELI3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- enzyme
- protein binding
- Pellino
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insulin resistance
- centrilobular necrosis
- obesity
- pervasive developmental disorder
- insomnia
- neurological disorder
- infection by Picornaviridae
role in cell
- degradation in
- activation in
- phosphorylation in
- cellular infiltration by
- hyperphosphorylation in
- function
- stabilization in
- K48 polyubiquitination in
- ubiquitination in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PELI3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- negative regulation of tumor necrosis factor-mediated signaling pathway
- regulation of Toll signaling pathway
- protein K63-linked ubiquitination
- negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding