Lgals12 Gene Summary [Mouse]
Predicted to enable lactose binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway. Located in mitochondrion and nucleus. Orthologous to human LGALS12 (galectin 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgals12 |
| Official Name | lectin, galactose binding, soluble 12 [Source:MGI Symbol;Acc:MGI:1929094] |
| Ensembl ID | ENSMUSG00000024972 |
| Bio databases IDs | |
| Aliases | lectin, galactose binding, soluble 12 |
| Synonyms | GAL12, galectin 12, GRIP1, lectin, galactose binding, soluble 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lgals12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GLECT
- lactose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- obesity
- impaired glucose tolerance
- primary prostate cancer
- Ullrich congenital muscular dystrophy
phenotypes
- abnormal free fatty acids level
- abnormal hormone level
- abnormal white adipose tissue physiology
- decreased brown adipose tissue mass
- decreased circulating leptin level
- decreased epididymal fat pad weight
- decreased inguinal fat pad weight
- decreased percent body fat/body weight
- decreased triglyceride level
- decreased white fat cell size
- enhanced lipolysis
- improved glucose tolerance
- increased circulating insulin level
- increased energy expenditure
- increased glycerol level
- increased insulin sensitivity
- increased oxygen consumption
- increased percent water in carcass
role in cell
- growth
- apoptosis
- signaling in
- differentiation
- cell cycle progression
- size
- mitochondrial respiration in
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- mitochondrial fraction
- Nucleus
- Mitochondria
- lipid droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lgals12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- lactose binding