Cspg4 Gene Summary [Mouse]
Enables coreceptor activity. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of MAPK cascade; and ruffle assembly. Located in plasma membrane and ruffle. Is expressed in several structures, including alimentary system; brain; genitourinary system; retina; and skeleton. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cspg4 |
| Official Name | chondroitin sulfate proteoglycan 4 [Source:MGI Symbol;Acc:MGI:2153093] |
| Ensembl ID | ENSMUSG00000032911 |
| Bio databases IDs | |
| Aliases | chondroitin sulfate proteoglycan 4 |
| Synonyms | 4732461B14Rik, AN2, chondroitin sulfate proteoglycan 4, chondroitin sulphate proteoglycan 4, Condroitin sulfate proteoglycan, Condroitin sulphate proteoglycan, Cspg, CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cspg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein kinase binding
- Cadherin-like
- LamG
- ectodomain
- signal peptide
- protein binding
- Bacterial cadherin-like domain
- cytoplasmic domain
- transmembrane domain
- intracellular domain
- collagen binding
- PDZ binding motif
- laminin G domain
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- mesothelioma
- mesothelioma formation
- insulin resistance
- neoplasia
- obesity
- renal clear cell adenocarcinoma
- renal clear cell cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- activation in
- phosphorylation in
- apoptosis
- proliferation
- growth
- number
- assembly
- inhibition
- development
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- membrane fraction
- Golgi lumen
- ruffle
- extracellular vesicles
- cell surface
- cell borders
- Extracellular Space
- cellular membrane
- somatic membrane
- lysosomal compartment
- nucleoplasm
- nodes of Ranvier
- basal lamina
- cellular protrusions
- microvilli
- basement membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cspg4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tissue remodeling
- ruffle assembly
- angiogenesis
- platelet-derived growth factor receptor signaling pathway
- substrate-dependent cell migration
- positive regulation of MAPK cascade
- positive regulation of peptidyl-tyrosine phosphorylation
- intracellular signal transduction
- glial cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- ruffle
- lysosomal lumen
- Golgi lumen
- extracellular region
- plasma membrane
- apical plasma membrane
- nucleoplasm
- cell surface
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- coreceptor activity