Polr3a Gene Summary [Mouse]
Enables chromatin binding activity. Predicted to be involved in innate immune response; positive regulation of interferon-beta production; and tRNA transcription by RNA polymerase III. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Wiedemann-Rautenstrauch syndrome and hypomyelinating leukodystrophy 7. Orthologous to human POLR3A (RNA polymerase III subunit A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr3a |
| Official Name | polymerase (RNA) III (DNA directed) polypeptide A [Source:MGI Symbol;Acc:MGI:2681836] |
| Ensembl ID | ENSMUSG00000025280 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) III (DNA directed) polypeptide A |
| Synonyms | 9330175N20Rik, ADDH, BC053071, C160, HLD7, hRPC155, polymerase (RNA) III (DNA directed) polypeptide A, RGD1305574, RNA polymerase III subunit A, RPC1, RPC155, WDRTS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-directed RNA polymerase, beta' subunit, predominant form
- RNA polymerase Rpb1, domain 1
- DNA-directed RNA polymerase subunit A'
- Largest subunit of RNA polymerase (RNAP), C-terminal domain
- RNA polymerase Rpb1, domain 3
- DNA-directed RNA polymerase
- nucleic acid binding
- RNA polymerase Rpb1, domain 4
- chromatin binding
- enzyme
- protein binding
- magnesium ion binding
- RNA polymerase Rpb1, domain 5
- zinc ion binding
- RNA polymerase Rpb1, domain 2
- Largest subunit of RNA polymerase (RNAP), N-terminal domain
- RNA polymerase I subunit A N-terminus
- DNA-directed RNA polymerase, subunit A''
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypomyelinating leukodystrophy type 7 without oligodontia or hypogonadotropic hypogonadism
- hypomyelinating leukodystrophy type 7
- Wiedemann Rautenstrauch syndrome
- leukodystrophy
- POLR3A-related disorder
- acute myeloid leukemia
- POLR3-related leukodystrophy
- movement disorder
- hypomyelinating leukodystrophy type 4
- Wiedemann-Rautenstrauch-like progeroid syndrome
regulates
- IFN beta
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- innate immune response
- positive regulation of interferon-beta production
- defense response to virus
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- DNA binding
- RNA polymerase III activity
- zinc ion binding
- protein binding
- DNA-directed RNA polymerase activity
- DNA/RNA hybrid binding
- chromatin binding