Orc4 Gene Summary [Mouse]
Predicted to enable DNA replication origin binding activity and nucleotide binding activity. Involved in polar body extrusion after meiotic divisions and protein polymerization. Acts upstream of or within DNA replication. Is active in cytoplasm. Is expressed in brain; embryo; and pancreas epithelium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Orc4 |
| Official Name | origin recognition complex, subunit 4 [Source:MGI Symbol;Acc:MGI:1347043] |
| Ensembl ID | ENSMUSG00000026761 |
| Bio databases IDs | |
| Aliases | origin recognition complex, subunit 4 |
| Synonyms | mMmORC4, ORC4L, Orc4l2, ORC4P, origin recognition complex subunit 4, origin recognition complex, subunit 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Orc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA ATPase domain
- ATPase family associated with various cellular activities (AAA)
- nucleotide binding
- ATPase domain predominantly from Archaea
- Origin recognition complex (ORC) subunit 4 C-terminus
- DNA replication origin binding
- protein binding
- ABC transporter
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Orc4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Orc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- polar body extrusion after meiotic divisions
- DNA-dependent DNA replication initiation
- protein polymerization
Cellular Component
Where in the cell the gene product is active
- origin recognition complex
- chromosome, telomeric region
- nucleus
- cytosol
- nuclear origin of replication recognition complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- nucleotide binding
- ATP binding
- DNA replication origin binding
- protein binding