Hsd17b6 Gene Summary [Mouse]
Enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in brexanolone catabolic process and retinol metabolic process. Predicted to be located in early endosome membrane and endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b6 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 6 [Source:MGI Symbol;Acc:MGI:1351670] |
| Ensembl ID | ENSMUSG00000025396 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 6 |
| Synonyms | 17betaHSD9, 3-HYDROXYSTEROID DEHYDROGENASE, 3(α-TO-β)-HSE, Hsd17b9, HSE, hydroxysteroid (17-beta) dehydrogenase 6, hydroxysteroid 17-beta dehydrogenase 6, hydroxysteroid (17-β) dehydrogenase 6, hydroxysteroid 17-β dehydrogenase 6, OXIDATIVE 3 alpha HYDROXYSTEROID DEHYDROGENASE, OXIDATIVE 3 α HYDROXYSTEROID DEHYDROGENASE, Rdh8, RL-HSD, RODH, SDR9C6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsd17b6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- 3beta(or 20alpha)-hydroxysteroid dehydrogenase
- electron carrier
- estradiol 17beta-dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- sepiapterin reductase
- 3alpha(or 20beta)-hydroxysteroid dehydrogenase
- 3-oxoacyl-(acyl-carrier-protein) reductase
- testosterone 17beta-dehydrogenase (NADP)
- retinol dehydrogenase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- prostate cancer
- hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- major depression
- non-small cell lung cancer
- non-small cell lung carcinoma
- uterine serous papillary cancer
- prostatic intraepithelial neoplasm
regulates
- androsterone
- epi-androsterone
- dihydrotestosterone
- 3-alpha,17-beta-androstanediol
- synthetic promoter
- ESR2
- CAT reporter gene
- allopregnanolone
- 3-beta,17-beta-androstanediol
- androgen
role in cell
- activation in
- morphology
- conversion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsd17b6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- androgen biosynthetic process
- retinol metabolic process
- steroid metabolic process
- androgen catabolic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- intracellular membrane-bounded organelle
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- estradiol 17-beta-dehydrogenase activity
- retinol dehydrogenase activity
- catalytic activity
- oxidoreductase activity
- testosterone dehydrogenase (NAD+) activity
- 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
- electron carrier activity
- testosterone 17-beta-dehydrogenase (NADP+) activity
- androsterone dehydrogenase activity