Myo1a Gene Summary [Mouse]
Enables actin filament binding activity. Acts upstream of or within microvillus assembly. Located in several cellular components, including basal plasma membrane; brush border; and lateral plasma membrane. Is expressed in several structures, including inner ear and intestine. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human MYO1A (myosin IA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo1a |
| Official Name | myosin IA [Source:MGI Symbol;Acc:MGI:107732] |
| Ensembl ID | ENSMUSG00000025401 |
| Bio databases IDs | |
| Aliases | myosin IA |
| Synonyms | BBM-I, DFNA48, MIHC, Myh1, MYHL, Myosin-1a, myosin IA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Calmodulin-binding motif
- Myosin and Kinesin motor domain
- peptidase
- protein binding
- Unconventional myosin tail, actin- and lipid-binding
- Myosin
- Myosin head (motor domain)
- IQ calmodulin-binding motif
Pathways
Biological processes and signaling networks where the Myo1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- headache
- colon cancer
- familial nonsyndromic hearing impairment
role in cell
- production
- morphology
- assembly
- organization
- localization
- redistribution in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- cortical actin cytoskeleton
- actin cytoskeleton
- actin filaments
- actin bundles
- lateral cell surfaces
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- growth cone
- membrane rafts
- brush border
- microvilli
- cell membrane leading edge
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- microvillus assembly
- actin filament organization
- vesicle localization
- endocytosis
- actin filament-based movement
Cellular Component
Where in the cell the gene product is active
- myosin complex
- lateral plasma membrane
- brush border
- microvillus
- cytoplasm
- actin cytoskeleton
- filamentous actin
- basolateral plasma membrane
- apical plasma membrane
- cortical actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- microfilament motor activity